Preheat oven to 350°. Spray a 15x10-inch rimmed baking sheet with cooking spray.
In a large Dutch oven, combine squash, onion, salt, and water to cover; bring to a boil over medium-high heat. Reduce heat to medium-low; simmer until tender, about 5 minutes. Drain.
In a medium bowl, stir together Cheddar and Gruyère.
Line bottom of prepared pan with whole crackers, overlapping slightly. Sprinkle with 3 cups cheese mixture.
Bake until cheese is melted, about 5 minutes. Leave oven on.
In another medium bowl, whisk together sour cream, mayonnaise, cream, eggs, and 1⁄2 teaspoon Cajun seasoning. Arrange squash mixture on top of whole crackers. Carefully pour egg mixture over squash mixture. Sprinkle with remaining 1 cup cheese mixture.
In a small bowl, stir together crushed crackers, melted butter, and remaining 1⁄2 teaspoon Cajun seasoning; sprinkle onto casserole.
Bake until center is set, 18 to 20 minutes. Let cool for 10 minutes. Garnish with parsley, if desired.
Notes
*We used Slap Ya Mama Cajun Seasoning.
Recipe by Paula Deen Magazine at https://pauladeenmagazine.com/sheet-pan-squash-casserole/